More than 120 injuries taking over three days to recover from took place in workplaces in the Royal Borough, the Health and Safety Executive (HSE) has reported.
The HSE said among the 129 total, 45 were major injuries, and no deaths between April 2010 to March 2011.
It also said the figure was down from the figure of 172 from April 2009 to March 2010.
In workplaces across Slough 221 over three-day injuries took place, 63 of which were major, and no death, down from the 223 last year.
The HSE's incident count report also said two people lost their lives at work in the whole of Berkshire, while 316 suffered a major injury.
Inspectors said high-risk industries included construction, agriculture, and waste and recycling.
The figures are provisional and will be finalised in June this year after any adjustments from investigations are made.
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The crash, which took place at about 7am today (Thursday), involved three vehicles. One man sadly died as a result of the collision and his next of kin have been informed.