Police and forensic teams are currently stationed outside a house near the Golden Ball pub in Marlow Road, Maidenhead.
At around 1.30pm today, two police cars were parked at the side of the road and a forensic van was parked by stables at the back of the house.
It is thought the cars have been there since late this morning.
Neighbours said they were unaware of why police were in the area.
Police have not yet released any details.
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The crash, which took place at about 7am today (Thursday), involved three vehicles. One man sadly died as a result of the collision and his next of kin have been informed.