A police cordon is in place at Boulters Lock in Maidenhead this morning.
The bridge which leads to Ray Mill Island has been taped off.
The cordon extends across the bridge and around the car park outside Boulters Riverside Brasserie.
All access to the island is being prevented by officers.
Police have not yet revealed any details of the incident.
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The crash, which took place at about 7am today (Thursday), involved three vehicles. One man sadly died as a result of the collision and his next of kin have been informed.