A motorist was taken to hospital with back injuries after a crash at the junction of Cannon Lane and Waltham Road in Woodlands Park.
The crash involved an Audi A3 and a Citroen.
A South Central Ambulance Service spokesman said that two rapid response vehicles and an ambulance went to the scene after being called out at 8.14am this morning.
One patient was taken to Wexham Park Hospital with back injuries.
Firefighters closed the road while the crash was being dealt with.
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The crash, which took place at about 7am today (Thursday), involved three vehicles. One man sadly died as a result of the collision and his next of kin have been informed.