Concerns have been raised about the impact of increased traffic if a new campus and private hospital are built at Claires Court's Ridgeway site in Maidenhead.
The proposals, announced last week, have been met with intrigue by nearby residents in Cannon Lane, but many said they wanted to know how the volume of cars will be kept under control.
The independent school wants to move all of its pupils, currently numbering just under 1,000, to a new building at its Junior Boys site, which is home to about 220 pupils.
It is also looking to sell land to the east of the school to build an acute hospital offering treatment to both NHS and private patients.
Cannon Lane resident Katie Croft said: "It has occurred to me that there will be more traffic which is never great but it's unavoidable."
The 32-year-old said she had concerns about building in the greenbelt but added: "I'm not up in arms because change happens."
Esther Weatherstone, said she was in favour of the hospital idea but warned traffic is 'going to be 10 times worse'.
The 43-year-old added: "It's mayhem enough for school kicking out time. It would be nice to see what the plans are for that."
Another resident, who asked not to be named, said the school, nearby housing estates and Foundation Park meant traffic was already an issue, particularly around the mini-roundabout leading into Ridgeway.
He said: "It's just diabolical and then you are going to have a hospital and more pupils coming in. There's going to be a lot more traffic."
Claires Court administrative principal Hugh Wilding said a transport and traffic survey would be an 'absolutely key and essential' part of the project.
He added: "We recognise at the school that the existing access is poor and needs to be improved.
"That may be through a new access from Cannon Lane but the whole point about consultation is that we get all views in order to come up with the best solution."
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