Police were called to a crash in Henley Road in Hurley at 5.35pm on Saturday.
Two cars, a Mercedes and a Peugeot 206, were involved.
The road was closed at Burchetts Green Roundabout until about 7.45pm to allow the vehicles to be recovered.
An ambulance was also called to the scene and one of the drivers was taken to hospital.
Top Ten Articles
The Met Office has issued a yellow alert for Windsor and Maidenhead, Slough and Wokingham, warning that rain moving eastwards across the south of the country may turn to snow in some places.