A decision on whether to move Oldfield Primary School to a new site in Bray Road is set to be made by councillors at a meeting on Wednesday.
The controversial move would see the school vacate its Chiltern Road premises in order to offer more places to pupils.
But members of the Bray Action Group (BRAG), who oppose the move, argue the new site is not suitable because it is situated on greenbelt land and in a flood plain.
It has also recently sent letters to borough councillors highlighting the impact an increase in traffic caused by the school would have on Bray Road.
The move has been recommended for approval by planning officers.
BRAG member Dr Barrie Mair said: "Unless the planning panel sees the sense in bringing this charade to a halt, we will have to rely on the Secretary of State to intervene."
Headteacher at Oldfield Primary School, Richard Jarrett, said he hoping the 'right decision' is made.
The meeting will take place at Maidenhead Town Hall, St Ives Road, at 7pm.
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