Accountancy group UHY Hacker Young says residents in the Royal Borough paid out £10,200 per person - the third highest average in the UK out of 100 areas.
This was a £6,640 higher than the £3,560 forked out per person in neighbouring Slough.
Householders in the Royal Borough stumped up a total of £829 million in tax each year, which was the 11th highest in the UK.
They forked out more than big cities such as Sheffield (£812 million), Cardiff (£589 million) and Newcastle (£443 million).
The total paid out in Slough was £232 million, placing it 87th.
The report was based on data taken from March 31, 2010 to March 31, 2011.
UHY Hacker Young says the latest income tax statistics show the UK is 'increasingly reliant on the wealthy Home Counties commuter belt for tax revenue'.
The ten places in the UK with the largest average income tax payments are all in the South east region of the UK.
Residents of Elmbridge in Surrey pay the highest average income tax bills with £16,100 per person per year, while the mean shelled out across the UK was £4,398.
London paid out the highest total amount of income tax with £33.7 billion, and Blackpool was the lowest paying out £159 million.
Mark Giddens, head of private client services at UHY Hacker Young, said wealth and tax bills were concentrated in a handful of cities and leafy suburbs in the UK.
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