More than 900 people were killed or seriously injured on roads across the Thames Valley last year.
The force says it aims to drive the figure down despite 63 fewer people being involved in serious crashes in 2012.
The number of fatal or serious injury collisions dropped from 972 in 2011 to 909 in 2012 - the lowest figure recorded for the Thames Valley since 2004.
Assistant Superintendent Henry Parsons, head of roads policing for the joint operations unit, said: "It’s encouraging news that the number of those killed or seriously injured has fallen so dramatically.
"However we have still had over 900 people who suffered injury or death on our roads last year. It remains our goal to help drive this figure down even more; working with partners in Road Safety and delivering both education and enforcement."
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The crash, which took place at about 7am today (Thursday), involved three vehicles. One man sadly died as a result of the collision and his next of kin have been informed.