It will shut between 10pm and 6am for the next seven nights (Monday to Friday only), with a signed diversion route in place via the A308 Windsor Road.
The closures are part of a project to repair sections of the road surface, and follow similar closures on the westbound carriageway last week.
On Saturday night there will be an additional overnight closure on the westbound carriageway at junction 8/9 with a diversion across the junction interchange, and on Sunday night the westbound entry slip road at the same junction will be closed with a diversion via junction 6.
All restrictions will be removed outside working hours.
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The Met Office has issued a yellow alert for Windsor and Maidenhead, Slough and Wokingham, warning that rain moving eastwards across the south of the country may turn to snow in some places.