The first steel frameworks for new homes have gone up where the Skindles Hotel once stood in Mill Lane.
The Berkeley Homes redevelopment of the area has made quick progress since planning permission was given by South Bucks District Council in September.
The new roundabout on the A4 is also due to be opened to traffic this summer.
The redevelopment of the old Skindles site and Regis Paper Mill in Mill Lane is set to become nearly 300 new homes as well as offices, a restaurant and provide new pedestrian access to the river.
On Saturday, April 16, the first phase of sales for the new homes was launched, with a positive response and interest from potential buyers.
Berkeley Homes has put the first offerings from Jubilee Meadows, on the Taplow Riverside development, on the market, with prices ranging from £1-2.5million.
A spokesperson from Berkeley Homes said: “The redevelopment between the Thames and Jubilee rivers has been a long time in the planning and it was lovely to see it finally launched. It promises to be an amazing new space. It will be a great place for those that are going to buy and live there, and for the wider Maidenhead residents.”
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The Met Office has issued a yellow alert for Windsor and Maidenhead, Slough and Wokingham, warning that rain moving eastwards across the south of the country may turn to snow in some places.